Journal of Animal Behaviour and Biometeorology
https://jabbnet.com/article/doi/10.31893/jabb.20025
Journal of Animal Behaviour and Biometeorology
Research Article Open Access

Anti-diabetic role of quercetin and cinnamon on neurobehavioral alterations and biochemical parameters of induced diabetics rats

Fella Boudiaf, Ibtissem Chouba, Naziha Amri, Abdelkarim Tahraoui

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Abstract

We aim was to evaluate the protective effects of the antioxidants cinnamon and quercetin on neurobehavioral alterations and complications, besides biochemical parameters of induced-diabetics Wistar rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin at a dose of (45 mg/kg). The administration of streptozotocin was considered acting on anxiety behaviors and biochemical parameters in adult Wistar rats. On the other hand, the protective role of antioxidants (cinnamon and quercetin) on streptozotocin-induced disorders was also evaluated. Behavioral tests in the open field (OF) revealed that diabetic animals exhibited an anxious behavior and an alteration in the locomotive and exploratory activities when compared to control. The administration of the cinnamon (2g/kg) and Quercetin (0.5g/kg) by gastric gavage reduces anxiety and decreases hyperglycemia-related harm. However, antioxidants cinnamon and quercetin administration significantly alleviated anxious and depressive behaviors.

Keywords

antioxidants, anxiety, diabetes

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Submitted date:
05/01/2020

Accepted date:
05/21/2020

5f8d81870e88250c74cb4689 jabbnet Articles
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